I've already have done that. That is how I meet my boyfriend. I'm quite talkative. hahaha
Specifically, I talked about scify, comics, fantasy books, travels, RPGs, noticed that he liked history and asked about that... Nerd people tend to be big on talking, you know. Of course, it helps to be able to notice the "hints" people left out in their pictures, comments, the inside jokes they made...
But if someone hit on you based on looks and doesn't care about what you think, chances are that the conversation won't work. After all, the guys who are big on soccer, might swipe right but have a hard time connecting with me. Nothing wrong, just a bad match.
But to answer your question, I've never have problem talking to people. You learn to do that at highschool. Even when they like things that you don't like. It is called "polite conversation" meant to avoid awkward silence. Most women know how to do it. If they don't you can translate that as "I'm not interested". In doubt, you can always make open questions as in "what are your hobbies?" "what do you like?" and that should give you information to keep talking.