The first point is interesting: "every man in her life is toxic". Many times, when talking about relationships, friendships or work, this is a sign that there is something that we are doing wrong or we need to work on.
If every relationship you have is with someone toxic, chances are that you are drawn to that and need to work to correct something in your life. Maybe you need to learn how to detect and avoid one kind of men. Maybe you are not ready for a relationship.
Regardless, the best those women can do is not date and keep their distance. Sadly, society presures women to date even when is not a good idea for them.